Neuropeptide Y Gene Polymorphisms Confer Risk of Early-Onset Atherosclerosis
نویسندگان
چکیده
منابع مشابه
Neuropeptide Y Gene Polymorphisms Confer Risk of Early-Onset Atherosclerosis
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). We have previously identified genetic linkage to familial CAD in the genomic region of NPY. We performed follow-up genetic, biostatistical, and functional analysis of NPY in early-onset CAD. In familial CAD (GENECARD, N = 420 families), we found increased microsatellite linkage to chromosome 7p14 (OSA LOD = 4.2, ...
متن کاملNeurogenic atherosclerosis mediated by neuropeptide y: hardening of the evidence.
Atherosclerosis is a complex, progressive vascular disease that represents an enormous clinical problem, being the principal cause of myocardial infarction and stroke and responsible for 50% of all mortality in westernized societies.1 Multiple risk factors for atherosclerosis are known to exist, including hypertension, hyperlipidemia, obesity, and smoking. Treatment of occlusive coronary athero...
متن کاملAssociation between Interleukin-10 gene polymorphisms and risk of early-onset preeclampsia.
We conducted a case-control study to investigate the role of IL-10 -1082A/G (rs1800896), -819T/C (rs1800871), and -592A/C (rs1800872) polymorphisms in the development of early-onset preeclampsia. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess the polymorphisms of IL-10 -1082A/G (rs1800896), -819T/C (rs1800871), and -592A/C (rs1800872). ...
متن کاملBARD1 Gene Polymorphisms Confer Nephroblastoma Susceptibility
BRCA1-associated RING domain protein 1 (BARD1) is a tumor suppressor, which forms a heterodimer with BRCA1. Three BARD1 gene polymorphisms (rs7585356 G>A, rs6435862 T>G and rs3768716 A>G) were initially identified as high-risk neuroblastoma susceptibility loci by a previous GWAS. Because of the general tumor-suppressing function of BARD1, we hypothesized that these BARD1 gene polymorphisms migh...
متن کاملPolymorphisms of the ITGAM Gene Confer Higher Risk of Discoid Cutaneous Than of Systemic Lupus Erythematosus
BACKGROUND Lupus erythematosus (LE) is a heterogeneous disease ranging from mainly skin-restricted manifestations (discoid LE [DLE] and subacute cutaneous LE) to a progressive multisystem disease (systemic LE [SLE]). Genetic association studies have recently identified several strong susceptibility genes for SLE, including integrin alpha M (ITGAM), also known as CD11b, whereas the genetic backg...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2009
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1000318